Methylmalonic Acid - LC-MS/MS

Methylmalonic acid (MMA) is an intermediate of amino acid metabolism which results from the conversion of propionyl-coenzyme A to succinyl-coenzyme A in a vitamin B12-dependent reaction, and is regarded as an early, sensitive biomarker of vitamin B12-deficiency. Vitamin B12-insufficiency leads to high concentrations of MMA in plasma, serum and urine. Our MassChrom® Methylmalonic Acid (MMA) kits allow the specific determination of methylmalonic acid in all three matrices.

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